No technique answers everything. The choice starts with the critical variable and the process matrix.
Process Raman
Inline probe / single-use
Real-time molecular signature
01 · MOLECULAR SIGNATURE
Follow the chemistry of culture in real time.
Chemometric models transform Raman spectra into estimates of metabolites and process attributes. The literature is strong in CHO culture, fermentation, perfusion and upstream.
Glucose, lactate and amino acids
Biomass and cellular concentration
Calibration transfer and models
Power control and consistency
Technical Note: the articles support the application Raman; the HORIBA configuration must be defined and validated for each process. The inline system announced with Fujifilm is in co-development.
Mass spectrometry online
O₂CO₂VOCs
GAM 2000 BioR · continuous off-gas analysis
02 · OFF-GAS MS
It converts the gas phase into metabolic information.
The GAM 2000 Bio R measures gases online in fermenters and bioreactors. With appropriate flows and corrections, the signs support respiratory calculations and reading of metabolic transitions.
O2, CO2 and additional gases
OUR, CER e RQ
VOCs and volatile by-products
Multiplexation of bioreactors
Decision map
The appropriate signal for each dimension
A practical reading of what each technology adds to the monitoring of the bioprocess.
Technology
Observa
Typical variables
Application in bioprocesses
Raman
Molecular composition
Glucose, lactate, amino acids and biomass
Cell culture monitoring, fermentation, infusion and PAT strategies
IPI GAM 2000 BioR
Gas phase
O2, CO2 and VOCs; OUR, CER and RQ by calculation
Continuous off-gas analysis in fermenters and bioreactors
Technical library
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Articles, application notes, material from manufacturers and revisions — organized by technology.
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Given the decision
Monitoring your process
SENS can help combine technique, sampling, integration and analytical strategy for your bioprocess.
Process Raman
