Natural abundance and low enrichment
Measure isotope ratios of individual analytes while preserving the molecular context.
Contact
Spectrometry of molecular isotope ratios
Orbitrap Isora MS
Isotopic and isotopologues ratios directly from molecular ions intact, combining electrospray ionization and mass detection exact in high resolution.
- Up to 480,000
- maximum resolution in m/z 200 with Isora Pro MS
- m/z 40–6.000
- mass range
- up to 40 Hz
- scan rate
From integrity to place
Three dimensions of the isotopic signature
Position-specific isotope analysis
Access position and functional group information by controlled fragmentation.
Clumped isotopes
Investigate isotopologues with multiple isotope substitutions rare.
Overview
From intact molecule to calibrated isotope ratio
Thermo Scientific Orbitrap Isora MS connects isotopic information and molecular structure in an integrated flow. Polar compounds are introduced by electrospray, preserving molecular integrity; the Orbitrap analyzer separates nearby isotopic species and the software transforms data HRAM on traceable results.
Sample introduction
Vanquish Duo UHPLC automates the alternation between sample and reference material for reproducible measurement conditions.
HRAM Acquisition
Orbitrap Isora combines ESI, high-resolution separation and dedicated acquisition strategies for measuring isotopes intact.
Treatment and calibration
Isotope Discoverer extracts, filters, corrects, calibrates and presents isotope ratios in a traceable flow.
Applications
Isotopic information with molecular context
The association between exact mass, isotopologues and molecular structure expands the depth of investigations in liquid samples.
Biogeochemistry
Study cycles of carbon, nitrogen, sulfur, oxygen and hydrogen nitrate, sulphate, phosphate, acetate, biomarkers and other compounds.
Metabolism and physiology
Follow metabolic transformations and unwind pathways complex using amino acids and other metabolites.
Environment
Investigate sources, routes and transformations of contaminants and environmental changes, including PFAS studies.
Geology, climate and archaeology
Relate isotopic signatures to training processes, atmospheric conditions, oxygen reservoirs and activity microbial.
Authenticity of food
Differentiate origins and processes with isotope ratios multi-element and position-specific in ingredients, aromas and Drinks.
Proxy development
Combine analysis of intact molecule and fragments for investigate reaction mechanisms and propose new indicators Isotopics.
Technical data
Orbitrap specifications Isora MS
Manufacturer published values for the Orbitrap Isora model Mass Spectrometer. Performance depends on method conditions.
BR-004587Official brochure • 07/2026
| Type | Mass spectrometer Orbitrap for isotope ratios (Orbitrap IRMS) |
|---|---|
| Mass range | m/z 40–6.000 |
| Maximum resolution | Up to 480,000 in m/z 200 with Isora Pro MS (up to 240.000 with Isora MS) |
| Scan rate | Up to 40 Hz |
| Dynamic range intra-scan | 5 magnitude orders |
| Ionization | Electrospray (ESI), OptaMax Plus font |
| Fragmentation | High-energy collisional dissociation (HCD) |
| Mass accuracy | External calibration: <3 ppm RMS; internal calibration: <1 ppm RMS, under defined conditions |
| Mass stability | EASY-IC: <1 ppm for at least 5 days; calibration of 1 point: <3 ppm for 4 weeks under defined conditions |
| MS dimensions (P × L × A) | 763 × 535 × 703 mm |
| Primary Vacuum Pump | A dry, oilless pump |
| Solution settings | Orbitrap Isora MS + Vanquish Duo UHPLC dedicado + Isotope Discoverer Software |
Orbitrap Isora family
System configurations
| Feature | Isora MS | Isora Pro MS |
|---|---|---|
| Maximum resolution | 240.000 | 480.000 |
| Scan rate | Up to 40 Hz | Up to 70 Hz |
| Mass range | m/z 40–6.000 | m/z 40–6.000 |
| Operation modes | isotope ratio and small molecules | isotope ratio, small molecules and peptides |
| Positioning | Molecular characterization and isotope analysis of small animals molecules | Advanced molecular characterization and isotope analysis of small molecules |
Models share sensitivity, mass accuracy, range linear dynamics and dynamic range intrascan with eDR. See SENS to set configuration and confirm availability.
Isotope Discoverer
From raw data to result that can be reviewed
Dedicated software brings together the main processing steps isotopic in a single environment, preserving traceability between extraction, filtering, correction and calibration.
Meet Isotope Discoverer- 01Extraction of isotope ratios in data HRAM
- 02Filtering, medium, summarization and drift correction
- 03Calibration of one or two points and calculation of delta values
- 04Visualization, quality control and Troubleshooting
- 05Export tables, files and reports structured
Frequently Asked Questions
Information about Orbitrap Isora
Structured content to support researchers, purchasing teams and search mechanisms in the evaluation of the solution.
What is Orbitrap Isora MS?
It's an Orbitrap mass spectrometer designed to measure isotope ratios and isotope ratios directly from ions molecular intact. The solution combines detection HRAM, ionization by electrospray, automated sample introduction and software Dedicated.
What types of isotope information does the system provide?
The system supports measurements in natural and low abundance enrichment, position-specific isotope analysis by controlled fragmentation and investigation of isotopologues with multiple rare substitutions, so-called Clumped isotopes.
What elements can be evaluated?
The manufacturer highlights the analysis of isotopologues related to carbon, nitrogen, oxygen, hydrogen and sulfur. A viability and performance depend on analyte, concentration, sample preparation, method and reference materials.
What is the difference between Orbitrap Isora and an IRMS approach Conventional?
Orbitrap Isora adds molecular context to isotopic information: preserves the molecule in electrospray ionization and separates isotopologues by exact mass in high resolution. This expands access to intact molecules, position-specific fragments and low-abundance isotopologues; does not mean that it replaces every conventional IRMS configuration.
What makes up the Orbitrap Isora solution?
The official configuration brings together Orbitrap Isora MS, a system Vanquish Duo UHPLC dedicated to the introduction and alternation of sample/reference and Isotope Discoverer Software for extraction, correction, calibration, visualization and reporting.
What is the difference between Isora MS and Isora Pro MS?
Both models share sensitivity, mass accuracy, linear dynamic range and mass range. The MS Isora reaches even 240.000 resolution and 40 Hz; Isora Pro reaches 480,000 and 70 Hz and adds resources for advanced molecular characterization and peptide flows. See SENS about the configuration available for your project.
Content Governance
Technical information with primary source
This pilot page uses only current official materials from Thermo Fisher Scientific. Applications and performance numbers must be read with the conditions and exceptions of the manufacturer.
- Official Orbitrap Page Isora Mass SpectrometerAcesso em 22/07/2026
- Orbitrap Isora MS brochure — BR-004587-EM-EN 0726Thermo Fisher Scientific, julho de 2026
- Isotope Discoverer brochure — BR004624-EM-EN 0626Thermo Fisher Scientific, junho de 2026
Project, method and infrastructure begin with the application.