Bioprocesses · offline and at-line analysis

Elemental composition and isotope signatures to understand biomass, substrates and metabolism.

From the balance of C, H, N, S and O to the distribution of isotopologues at molecular level: three analytical approaches for the development, optimization and characterization of bioprocesses.

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CompositionFlashSmartCHNS/O, C/N and N/protein

isotope ratioIRMSIsotopes in total sample or specific compound

Molecular contextOrbitrap ISORAisotopologues, HRAM and position-specific analysis

Analytical objective

Information obtained

Select a goal. The page highlights the most appropriate analytical route — and when it is worth combining techniques.

Recommended route

FlashSmart for Elemental Composition and Protein

Quantify CHNS/O, C/N ratio and total nitrogen to compare biomass, media, substrates, residues and bioprocess products.

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01 · Elemental analysis

FlashSmart

Turn biomass, media, substrates and products into quantitative composition data. The platform brings together analysis of C, H, N, S and O with settings for C/N and nitrogen/protein.

Microbial biomassMeans and substratesWastes and co-productsProtein

C/N balance sheet and biomass composition

Total nitrogen and protein estimation

Characterisation of solid currents

Comparison of cultivation conditions

Elemental analysis CHNS/O

Offline/at-line characterization

02 · isotope ratio

IRMS

Measure natural or enriched isotopic signatures to accompany the origin and incorporation of carbon, nitrogen, sulfur, oxygen and hydrogen in bioprocesses.

¹³C e ¹⁵NEA-IRMSGC-IRMSBioproducts

Incorporation of marked substrates

Carbon and nitrogen tracking

Isotopic biomass balance

Signature of specific compounds

DELTA Q with EA/GC interfaces

High precision isotope ratio

03 · Orbitrap isotope ratio MS

Orbitrap ISORA

Connect isotope ratio, exact mass and molecular structure. ISORA preserves the context of analyte to investigate isotopologues, low-level enrichment and intramolecular distribution.

isotopologuesIsotope tracingHRAMPSIA

Isotopic analyte ratios

Tracers in cellular metabolism

Controlled Fragmentation and PSIA

Isotope Integration Discoverer

Orbitrap ISORA with Vanquish system on clear background

Orbitrap ISORA Mass Spectrometer

Molecular isotope information

Technical library

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Articles, application notes, materials from manufacturers and theses — organized by solution.

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Application assessment

Talk to SENS about matrix, concentration range, isotopic tracer, sample preparation and analytical flow more appropriate to your bioprocess.

Telephone+55 (11) 5031.3231
+55 (11) 96647.5918

Emailcontato@sensms.com.br

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Sala 18 - Bloco 1
Vila Hamburguesa - São Paulo - SP
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